VATICAN CITY — Pope Leo XIV leaves Rome on Friday, Nov. 6, for an apostolic journey to South America, his first visit there since his election as pope.
The trip will take him to three countries, including Uruguay and Argentina, and culminate in Peru, where he served as a missionary and bishop for about 20 years.
Like most papal trips, this will be a mix of the pastoral and the political, featuring meetings with heads of state and other dignitaries; addresses to the local hierarchy, clergy, and religious; large outdoor Masses; youth vigils; and visits to Church-affiliated charitable institutions.
But this journey will be extraordinary in at least two ways. For one thing, it comes a little more than three weeks after Leo underwent surgery for lung cancer. His doctors have said he needs no further treatment, but his decision not to reduce his schedule, which features more than 40 public and private events, is nonetheless striking. The itinerary will take him to 14 cities and towns, including Cusco, Peru, which lies more than 11,000 feet above sea level.
The other distinctive aspect of the trip, which may help explain Leo's determination to make it, is its highly personal nature. The pope will spend five of his 11 days on the continent in Peru, two of them in his former diocese of Chiclayo. The first U.S.-born pontiff, Leo is also a naturalized citizen of Peru, where he spent almost half of his 43 years as a priest before becoming pope.
Leo is the first pope in centuries to have served as a foreign missionary, and that experience is central to his identity. As he said upon arriving in Rome in 2023 to take up a new role as a Vatican official: "I still consider myself a missionary. My vocation, like that of every Christian, is to be a missionary, to proclaim the Gospel wherever one is."
His return to his former mission field will highlight the history of his vocation, as he retraces key steps on his path to leadership of the Church.
According to Father Arthur Purcaro, a fellow Augustinian and companion of then-Father Robert Prevost in Peru, the future pope was changed by his experience in the country, where he encountered a new culture, served the poor amid great social turbulence, and "learned that the Church is for the world and we're not self-referential."
Returning now as pontiff, Leo "will be reaching out, to have the eyes of the world see somebody's knocking at the door," Purcaro said in an interview. "That perhaps might help people anywhere around the world understand that that's part of what the mission of the Church is: to open our door, to embrace. … That's part of who he learned to be and is. And I believe it's part of why he's going to these three countries now."
Leo's journey to his adoptive continent will also showcase diverse forms of evangelization that the Church practices today.
Catholic missionary work, strictly speaking, has traditionally been aimed at peoples and places where the Church is absent or not well established. But especially since the Second Vatican Council, the Church has increasingly spoken of mission more broadly to include, among other activities, "the new evangelization," or efforts to revive the faith among baptized people who have drifted away from religious practice or who no longer identify as Catholic.
Such efforts are particularly relevant to the first country on Leo's itinerary, Uruguay, one of the most secular countries in Latin America, where more than half the population has no religious affiliation and 28% are agnostic or atheist. Under a law dating to 1919, the state's official calendar lists Christmas as "Family Day," Holy Week as "Tourism Week," the Epiphany as "Children's Day," and the Immaculate Conception as "Beaches Day."
Evangelization in such an environment is "a very great challenge," Bishop Milton Tróccoli of Maldonado-Punta del Este-Minas, president of the Uruguayan Bishops' Conference, told "EWTN Noticias" in September. The local Church considers Uruguay "a mission country where we must proclaim the Gospel extensively," Tróccoli said.
Uruguayan secularism reflects the influence of the French model of "laïcité," and Leo's approach to the matter could well echo his remarks on his last international trip, to France in September. There, in his speech to President Emmanuel Macron and other dignitaries, the pope argued that religious believers and institutions should have a role in public life.
In another echo of his visit to France, where he denounced the country's recent legalization of assisted dying, Leo is also likely to criticize Uruguay's recent legalization of euthanasia. (Euthanasia is the intentional ending of a human life for the purpose of relieving suffering. In assisted dying, a patient takes life-ending drugs himself under the guidance of a physician. Catholic moral teaching prohibits both practices.)
In Argentina, Leo's visit will inevitably be seen in light of the memory of its native son Pope Francis, who never visited the country during his 12-year pontificate. Leo has vowed to continue his predecessor's signature initiative of synodality, which seeks to give lay Catholics a greater voice in Church governance and teaching.
Francis said that "synodality is essentially missionary" and that mission is "always synodal," suggesting that clergy, religious, and laypeople should listen to one another and work together in proclaiming the Gospel. At Leo's meetings with the bishops of Argentina and Peru, a standard feature of papal visits, local teams responsible for implementing the synodal process will also be included, a sign of the importance that the current pope gives to the topic.
Although Pope Francis was known as an innovator, and even a disruptor of tradition, he was also a champion of popular piety, particularly devotion to the Virgin Mary. Pope Leo XIV will honor that practice on his upcoming pilgrimage to the Argentine city of Luján, home to a revered image of Mary that draws millions of pilgrims each year, and drew more than 2.8 million for a youth pilgrimage in October.
Leo's visits to Uruguay and Peru will likewise include important Marian shrines: the National Shrine of Our Lady of the Thirty-Three in Uruguay and the Shrine of Our Lady of Peace in Peru. Leo will also crown an image of the Immaculate Virgin at the cathedral in his former diocese of Chiclayo.
According to Bishop Edinson Farfán, Leo's successor as bishop of Chiclayo, popular piety is a "great ally" in facing one of the greatest challenges to Catholicism in Latin America today: competition from Pentecostal churches. "Popular piety reaches everywhere, especially peripheral areas," where priests seldom visit but Pentecostals are well-established, Farfán told reporters at a briefing last month organized by the charitable organization Aid to the Church in Need.
The Peru leg of the pope's trip will highlight an important element of evangelization: the practice of inculturation, or expressing Catholic teachings and forms of worship in terms of local cultures. A key figure in this tradition is St. Turibius de Mogrovejo, a Spanish missionary who served as archbishop of Lima from 1581 until his death in 1606 and who promoted the use of the Indigenous languages Quechua and Aymara in evangelization.
Pope Leo, who studied Quechua during his time in Peru, has a particular devotion to St. Turibius. Then-Father Prevost spent the night before his ordination as a bishop in December 2014 praying before a relic of the saint in a chapel in the town of Zaña. Now pope, he will return to the town, a historic center of Afro-Peruvian culture, on Nov. 14 for a closing celebration of the jubilee year marking the 300th anniversary of St. Turibius' canonization.
During his visit to South America, the pope will visit centers of the Church's charitable activity, a traditional concomitant of mission work, including homes for disabled people near Buenos Aires, Argentina, and for abandoned elderly people in Lima, Peru.
Leo will also engage in a form of outreach that has become especially urgent in recent years, following scandals over clerical sexual abuse. The Vatican has said Leo will hold some meetings with abuse victims during his time in South America. These could include people involved in the Sodalitium case. As bishop of Chiclayo, Leo personally assisted victims of abuse by members of the Sodalitium Christianae Vitae, a Catholic organization suppressed by the Vatican in 2025.
The pope's last full day in Peru before returning to Rome will be in some ways the most ambitious, and a dramatic illustration of the Church's missionary efforts. In the morning, he will fly to Cusco in the Andean highlands, where he will meet representatives of popular Catholic devotion at an Inca archaeological site. A few hours later, he will meet missionaries and representatives of Amazonian Indigenous peoples and celebrate Mass in the rainforest. The difficulty of providing the sacraments to remote parts of the Amazon was a major theme of the Amazon Synod that Pope Francis called at the Vatican in 2019.
"The pope's presence will make us visible," said Father David Farfán, a priest of the Diocese of Chiclayo (with no family relation to the bishop of the same surname). "It will draw attention to those places in the heartland of Peru — and indeed anywhere in the world — where communities have been forgotten, rejected, and left behind."



















